Silver nanoparticles in denture adhesive: An antimicrobial approach against Candida albicans

Autor(es)

Peralta, Laura Catali Ferreira ; Almeida, Nara Ligia Martins ; Pontes, Fenelon Martinho Lima ; Rinaldo, Daniel ; Carneiro, Camila Alves ; Neppelenbroek, Karin Hermana ; Lara, Vanessa Soares ; Porto, Vinicius Carvalho

• Tipo de documento: Artigo Científico
• Fonte: Journal of Dentistry; v. 131, p. 11-pg., 2023-02-21.

Resumo

Objective: To evaluate the antimicrobial potential of silver nanoparticles (Ag NPs) synthesized using three different routes (ultraviolet light, Turkevich, and green chemistry method using Glycine max extract) associated with COREGA (R) denture powder adhesive.Methods: Heat-cured acrylic resin specimens were treated with different Ag NPs associated with the adhesive (AD + Ag UV, AD + Ag Turk, and AD + Ag Gm groups). As controls, the specimens were treated with a combination of adhesive and nystatin (AD + Nyst group), only adhesive (AD group), or submerged on the surface of the specimens (PBS group). After the treatments, biofilms of C. albicans developed for 3, 6, and 12 h on the specimen surfaces. The biofilm was quantified using colony-forming units per milliliter, colorimetric assay, and confocal laser scanning microscopy. Results: Regardless of the period, we observed an inhibition of fungal load and a reduction in metabolic activity and biofilm mass in the resin specimens treated with the combinations AD/Ag NPs, compared to AD and PBS. The antimicrobial action of the AD + Turk and AD + Ag Gm groups was similar than that for the AD + Nyst group in all periods and viability tests, except for the biofilm mass (12 h).Conclusions: The COREGA (R) adhesive with Ag NPs, mainly those synthesized using the Turkevich and Glycine max methods, showed excellent antimicrobial activity against C. albicans biofilms, maintained for up to 12 h. Clinical significance: The association of Ag NPs to the adhesive can add preventive or therapeutic effects against denture stomatitis, to this prosthetic material. (AU)

• Processo FAPESP: 11/20536-7 - Materiais Ferroelétricos Multifuncionais: Estudos das Propriedades Ópticas, Elétricas e Fotoluminescente.
• Beneficiário: Debora da Silva Lima Pontes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado