Organoids as a novel tool in modelling infectious diseases

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de Oliveira, Lucas Felipe ; Mendes Filho, Daniel ; Marques, Bruno Lemes ; Maciel, Giovana Figueiredo ; Parreira, Ricardo Cambraia ; Neto, Jose Rodrigues do Carmo ; Da Silva, Priscilla Elias Ferreira ; Guerra, Rhanoica Oliveira ; da Silva, Marcos Vinicius ; Santiago, Helton da Costa ; Birbrair, Alexander ; Kihara, Alexandre H. ; da Silva, Valdo Jose Dias ; Glaser, Talita ; Resende, Rodrigo R. ; Ulrich, Henning

• Tipo de documento: Artigo Científico
• Fonte: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; v. 144, p. 10-pg., 2023-03-17.

Resumo

Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue ar-chitecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host-infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/11667-0 - Alterações celulares e eletrofisiológicas no hipocampo causadas por processos neurodegenerativos relacionados com anóxia neonatal e epilepsia do lobo temporal
• Beneficiário: Alexandre Hiroaki Kihara
• Modalidade de apoio: Auxílio à Pesquisa - Regular