| Texto completo | |
| Autor(es): |
Dos Santos, Benedito M.
;
Przyborski, Jude M.
;
Garcia, Celia R. S.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 8, p. 11-pg., 2023-04-01. |
| Resumo | |
During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in cytosolic calcium. In the present report, we summarize the information available in the literature regarding the role of potassium ions during parasite development. A deeper understanding of the mechanisms that allow the parasite to cope with ionic potassium changes contributes to our knowledge about the cell cycle of Plasmodium spp. (AU) | |
| Processo FAPESP: | 17/08684-7 - Decodificar aspectos da biologia celular e molecular do Plasmodium como uma ferramenta para desenvolver novos antimaláricos |
| Beneficiário: | Célia Regina da Silva Garcia |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/08988-9 - Avaliação de compostos com potencial antimalárico e estudo do mecanismo de transdução de sinal do GPCR (G-Protein Coupled Receptor) like PfSR25 em Plasmodium falciparum |
| Beneficiário: | Benedito Matheus dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |