Characterization of KPC-2-producing Klebsiella pneumoniae and affected patients of a pediatric hospital in Brazil

Autor(es)

Barroso, Marlon do Valle ; da Silva, Caroline R. ; Benfatti, Luisa R. ; Gozi, Katia S. ; de Andrade, Letcia K. ; Andrade, Leonardo N. ; Estofolete, Cassia F. ; Nogueira, Mara C. L. ; Casella, Tiago

• Tipo de documento: Artigo Científico
• Fonte: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 106, n. 2, p. 7-pg., 2023-04-04.

Resumo

Carbapenemase-producing Klebsiella pneumoniae (CPKp) infections are important threats to pediatric popu-lations. Thus, a retrospective study was conducted in a Brazilian reference pediatric hospital, and 26 CPKp isolates obtained from 23 patients were characterized. The affected population had important underlying diseases, reflecting previous hospitalization and antibiotic use. Most CPKp isolates were resistant to all anti-biotic classes, and blaKPC-2 was the only carbapenemase-encoding gene. blaCTX-M-15 was common among the isolates, and modification or absence of the mgrB gene was the cause of polymyxin B resistance. Ten different sequence types were identified, and clonal complex 258 was prevalent. Alleles wzi50 and wzi64 were the most recurrent ones regarding K-locus type, with a remarkable contribution of the epidemic ST11/KL64 line-age as a colonizer. Our findings show that lineages associated with the pediatric population are similar to those found in adults, reinforcing the need for epidemiological surveillance to effectively implement preven-tion and control measures.(c) 2023 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 20/08482-8 - Clones de alto risco de Klebsiella pneumoniae resistentes a ß-lactâmicos de amplo espectro: uma perspectiva em Saúde Única
• Beneficiário: Tiago Casella
• Modalidade de apoio: Auxílio à Pesquisa - Regular