| Texto completo | |
| Autor(es): |
Prado, Cibele M.
;
Rossi, Marcos A.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | OPEN CARDIOVASCULAR MEDICINE JOURNAL; v. 2, p. 8-pg., 2008-01-01. |
| Resumo | |
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress. (AU) | |
| Processo FAPESP: | 06/59618-0 - O possível papel do complexo de glicoproteínas associadas à distrofia na morte súbita na tripanossomiase americana experimental |
| Beneficiário: | Marcos Antonio Rossi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 01/09879-8 - Endotélio vascular, forças hemodinâmicas, hipertensão e aterogênese |
| Beneficiário: | Marcos Antonio Rossi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/52882-3 - O possível papel do complexo de glicoproteínas associadas à distrofina na morte súbita na tripanosomíase americana experimental |
| Beneficiário: | Cibele Maria Prado Zinni |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |