| Texto completo | |
| Autor(es): |
Mendes-Junior, Celso T.
;
Castelli, Erick C.
;
Moreau, Philippe
;
Simoes, Aguinaldo L.
;
Donadi, Eduardo A.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HUMAN IMMUNOLOGY; v. 71, n. 4, p. 4-pg., 2010-04-01. |
| Resumo | |
The HLA-G gene is predominantly expressed at the maternal-fetal interface and has been associated with maternal-fetal tolerance. The HLA-G*0113N is a null allele defined by the insertion of a premature stop codon at exon 2, observed in a single Ghanaian individual. Likewise the G*0105N allele, the occurrence of the HL4-G*0113N in a population from an area with high pathogen load suggests that the reduced HLA-G expression in G*0113N heterozygous placentas could improve the intrauterine defense against infections. The presence of the G*0113N allele here was investigated in 150 Amerindians from five isolated tribes that inhabit the Central Amazon and in 295 admixed individuals from the State of Sao Paulo, Southeastern Brazil, previously genotyped for HLA-G. No copy of the G*0113N null allele was found in both population samples by exon 2 sequence-based analysis, reinforcing its restricted occurrence in Africa. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 09/06191-7 - 5th International Conference on HLA-G |
| Beneficiário: | Celso Teixeira Mendes Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Reunião - Exterior |
| Processo FAPESP: | 07/58420-4 - Polimorfismos da região promotora e expressão de HLA-G em pacientes com histórico de carcinoma de células transicionais da bexiga urinária |
| Beneficiário: | Erick da Cruz Castelli |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 07/58391-4 - Diversidade genética do gene HLA G em populações indígenas brasileiras |
| Beneficiário: | Celso Teixeira Mendes Junior |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |