| Texto completo | |
| Autor(es): |
Ferreira, Camila G.
;
Avalloni, Tania M.
;
Oshima-Franco, Yoko
;
Oliveira, Sara de J.
;
de Oliveira, Jose M., Jr.
;
Cogo, Jose C.
;
Vanin, VR
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | XXXIII BRAZILIAN WORKSHOP ON NUCLEAR PHYSICS; v. 1351, p. 4-pg., 2011-01-01. |
| Resumo | |
The aim of this work was to reduce the toxicity of Bothrops jararacussu venom using gamma-rays of low-energy coming from a source of Americium-241 (E=59.6 keV and 3.7x10(9) Bq of activity) in order to obtain a toxoid. The radiation dose that each sample received was controlled by exposure time of the venom to the radiation beam. Mouse nerve phrenic-diaphragm preparation was used for testing the loss of venom toxicity, since the venom causes an irreversible neuromuscular blockade. In this condition, the several samples of irradiated venom, when assayed in neuromuscular preparation showed that with a dose of 0.051 Gy the paralysis caused by the irradiated venom was of 91%, at 0.360 Gy was of 79%, at 1.662 Gy was of 50% and at 2.448 Gy was of 42%. Therefore, it can be concluded that the irradiation model was able to induce a progressive loss of the venom toxicity. (AU) | |
| Processo FAPESP: | 04/09705-8 - Investigacao farmacologica da atividade antipeconhenta de fracoes obtidas de extratos de casearia sylvestris sw. |
| Beneficiário: | Yoko Oshima Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 07/53883-6 - Dipteryx alata vogel: estudo da acao antiofidica e da toxicidade. |
| Beneficiário: | Yoko Oshima Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |