Autor(es)

Brassesco, Maria Sol ; Xavier, Danilo Jordao ; Camparoto, Marjori Leiva ; Montaldi, Ana Paula ; D'Auria Vieira de Godoy, Paulo Roberto ; Scrideli, Carlos Alberto ; Tone, Luiz Gonzaga ; Sakamoto-Hojo, Elza Tiemi

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; v. N/A, p. 8-pg., 2011-01-01.

Resumo

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort. (AU)

• Processo FAPESP: 03/01915-0 - Análise citogenética e molecular de translocações cromossômicas no gene MLL para avaliar os efeitos tardios da quimioterapia em linfócitos de pacientes em alta que apresentaram Leucemia Linfoide Aguda na infância
• Beneficiário: María Sol Brassesco Annichini
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 02/13317-8 - Estudo citogenetico e molecular da instabilidade genomica em resposta a lesoes induzidas no dna pela radiacao ionizante e compostos antitumorais em celulas humanas.
• Beneficiário: Elza Tiemi Sakamoto Hojo
• Modalidade de apoio: Auxílio à Pesquisa - Regular