| Texto completo | |
| Autor(es): Mostrar menos - |
Storti-Melo, Luciane M.
;
Souza-Neiras, Wanessa C.
;
Cassiano, Gustavo C.
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Taveira, Leonardo C.
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Cordeiro, Antonio J.
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Couto, Vanja S. C. A.
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Povoa, Marinete M.
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Cunha, Maristela G.
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Echeverry, Diana M.
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Rossit, Andrea R. B.
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Arevalo-Herrera, Myriam
;
Herrera, Socrates
;
Machado, Ricardo L. D.
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | American Journal of Tropical Medicine and Hygiene; v. 84, n. 2, p. 6-pg., 2011-02-01. |
| Resumo | |
Frequency and levels of IgG antibodies to an N-terminal fragment of the Plasmodium vivax MSP-1 (Pv200L) protein, in individuals naturally exposed to malaria in four endemic areas of Brazil, were evaluated by enzyme-linked immunosorbent assay. Plasma samples of 261 P vivax-infected individuals from communities of Macapa, Novo Repartimento, Porto Velho, and Placido de Castro in the Amazonian region with different malaria transmission intensities. A high mean number of studied individuals (89.3%) presented with antibodies to the Pv200L that correlated with the number of previous malaria infections; there were significant differences in the frequency of the responders (71.9-98.7) and in the antibody levels (1:200-1:51,200) among the four study areas. Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites. The fine specificity of antibodies to Pv200L is currently being assessed. (AU) | |
| Processo FAPESP: | 02/09546-1 - Epidemiologia e diagnóstico molecular de doenças infecciosas e parasitárias humanas |
| Beneficiário: | Andrea Regina de Souza Baptista |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |