Exploratory analysis of the serum ionomic profile for bipolar disorder and lithium treatment

Autor(es)

Sussulini, Alessandra ; Banzato, Claudio E. M. ; Arruda, Marco A. Z.

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MASS SPECTROMETRY; v. 307, n. 1-3, p. 3-pg., 2011-10-01.

Resumo

In the present work, a very simple and fast experimental design using ICP-MS was employed to search for differentiations in the levels of free ions present in human blood serum samples obtained from healthy individuals (n = 25) and bipolar disorder (BD) patients under different treatments: (i) using lithium (n = 15) and (ii) using other drugs than lithium (n = 10). Fourteen ions that showed statistically significant alterations in its levels when comparing the studied groups were detected, providing a hint for further studies on BD and lithium treatment biomarker discovery. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/58073-0 - Avaliação de possíveis biomarcadores do transtorno afetivo bipolar a partir da análise de proteínas e metaloproteínas em soro sanguíneo
• Beneficiário: Alessandra Sussulini
• Modalidade de apoio: Bolsas no Brasil - Doutorado