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Obesity: considerations about etiology, metabolism, and the use of experimental models

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Autor(es):
Pereira-Lancha, Luciana O. ; Campos-Ferraz, Patricia L. ; Lancha, Antonio H., Jr.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY; v. 5, p. 13-pg., 2012-01-01.
Resumo

Studies have been conducted in order to identify the main factors that contribute to the development of obesity. The role of genetics has also been extensively studied. However, the substantial augmentation of obesity prevalence in the last 20 years cannot be justified only by genetic alterations that, theoretically, would have occurred in such a short time. Thus, the difference in obesity prevalence in various population groups is also related to environmental factors, especially diet and the reduction of physical activity. These aspects, interacting or not with genetic factors, could explain the excess of body fat in large proportions worldwide. This article will focus on positive energy balance, high-fat diet, alteration in appetite control hormones, insulin resistance, amino acids metabolism, and the limitation of the experimental models to address this complex issue. (AU)

Processo FAPESP: 96/08618-6 - Avaliacao da atividade fisica seguido de controle alimentar na composicao corporal de mulheres obesas pre-menopausa.
Beneficiário:Luciana Oquendo Pereira Lancha
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica