Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action

Autor(es)

Nicastro, Humberto ; da Luz, Claudia Ribeiro ; Seixas Chaves, Daniela Fojo ; Grassmann Bechara, Luiz Roberto ; Voltarelli, Vanessa Azevedo ; Rogero, Marcelo Macedo ; Lancha, Antonio Herbert, Jr.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NUTRITION AND METABOLISM; v. 2012, p. 10-pg., 2012-01-01.

Resumo

Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation. (AU)

• Processo FAPESP: 09/52022-2 - Efeitos da suplementação com leucina nas vias de sinalização da síntese protéica em músculos sóleo e EDL de ratos jovens e idosos
• Beneficiário: Daniela Fojo Seixas Chaves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/04690-6 - Efeitos da suplementação de leucina e aminoácidos de cadeia ramificada no dano e inflamação muscular aguda induzida pelo exercício de força: um estudo randomizado, duplo-cego, e controlado por placebo
• Beneficiário: Claudia Ribeiro da Luz
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/07062-3 - Leucina e desuso muscular: eficácia clínica anti-atrófica e mecanismos relacionados
• Beneficiário: Humberto Nicastro Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto