Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity

Autor(es)

Melo Luvizotto, Renata de Azevedo ; do Nascimento, Andre Ferreira ; de Sibio, Maria Teresa ; Castro Olimpio, Regiane Marques ; Conde, Sandro Jose ; Lima-Leopoldo, Ana Paula ; Leopoldo, Andre Soares ; Cicogna, Antonio Carlos ; Nogueira, Celia Regina

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC WORLD JOURNAL; v. N/A, p. 7-pg., 2012-01-01.

Resumo

Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)-fed with commercial chow ad libitum-and obese (OB)-fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25 mu g triiodothyronine (T-3)/100 BW (OT). The T-3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T-3 treatment was effective, increasing fT(3) levels and decreasing fT(4) and TSH serum concentration. Administration of T-3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T-3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T-3 and adipokines in obesity. (AU)

• Processo FAPESP: 06/58177-0 - Influencia de diferentes doses de triiodotironina sobre adipocinas na obesidade e apos a perda de peso.
• Beneficiário: Renata de Azevedo Melo Luvizotto Nascimento
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/50041-4 - Associacao de leptina, resistina, adiponectina e hormonios tireoidianos na obesidade e na perda de peso.
• Beneficiário: Celia Regina Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular