Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease

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de Souza Pinhel, Marcelo Augusta ; Sado, Caroline Leiko ; Longo, Gabriela dos Santos ; Gregorio, Michele Limo ; Amorim, Gisele Sousa ; da Silva Florim, Greiciane Maria ; Mazeti, Camila Montoro ; Martins, Denise Poltronieri ; Oliveira, Fabio de Nazare ; Nakozone, Marcelo Arruda ; Tognola, Waldir Antonio ; Silva Souza, Doroteia Rossi

• Tipo de documento: Artigo Científico
• Fonte: Arquivos de Neuro-Psiquiatria; v. 71, n. 8, p. 6-pg., 2013-08-01.

Resumo

Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the chi(2) test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1. (AU)

• Processo FAPESP: 08/53950-8 - Relevancia das variantes geneticas de lrrk2 e glutationa s-transferases para doenca de parkinson
• Beneficiário: Waldir Antonio Tognola
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/18476-6 - Impacto das Variantes Genéticas da Apolipoproteína E no Perfil Lipídico em Pacientes com Doença de Parkinson
• Beneficiário: Caroline Leiko Sado
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica