Effect of percutaneous transthoracic lung biopsy on oxidative metabolism in sheep

Autor(es)

Silva, Andreza A. ; Ferreira, Danilo O. L. ; Santarosa, Bianca P. ; Dias, Adriano ; Damasceno, Debora C. ; Goncalves, Roberto C.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE SOUTH AFRICAN VETERINARY ASSOCIATION; v. 83, n. 1, p. 5-pg., 2012-01-01.

Resumo

This study aimed to assess the effect of percutaneous transthoracic lung biopsy on the oxidative metabolism of sheep by measuring the oxidative stress markers of superoxide dismutase (SOD), total glutathione (GSH-t), peroxidase (GSH-Px) and thiobarbituric acid reactive substances (TBARS) in the red cells of these animals. Blood samples were collected from 20 clinically healthy sheep prior to, and 30 min after, percutaneous transthoracic lung biopsy. After biopsy, there was a significant decrease (p < 0.05) in SOD and GSH-Px activity, with no significant change (p >= 0.05) in GSH-t and TBARS concentrations. These results showed that percutaneous transthoracic lung biopsy did not significantly affect the oxidative metabolism of sheep 30 min after the procedure, which may be used widely in this species without causing serious tissue damage. (AU)

• Processo FAPESP: 07/55341-6 - Avaliacao da tecnica de biopsia pulmonar transtoracica em ovinos clinicamente sadios e os efeitos do procedimento sobre o estresse oxidativo no sangue desses animais.
• Beneficiário: Roberto Calderon Gonçalves
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/51713-6 - Avaliacao da tecnica de biopsia pulmonar transtoracica em ovinos clinicamente sadios e os efeitos do procedimento sobre o estresse oxidativo no sangue de sses animais.
• Beneficiário: Andreza Amaral da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado