| Texto completo | |
| Autor(es): |
Toledo, Thais Regina
;
Dejani, Naiara N.
;
Silva Monnazzi, Luis Gustavo
;
Kossuga, Miriam H.
;
Berlinck, Roberto G. S.
;
Sette, Lara D.
;
Medeiros, Alexandra I.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Mediators of Inflammation; v. 2014, p. 11-pg., 2014-01-01. |
| Resumo | |
Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G) K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2. Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1). Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway. Moreover, pyrenocine A is also able to inhibit the expression of genes related to NF kappa B-mediated signal transduction on macrophages stimulated by LPS. Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model. (AU) | |
| Processo FAPESP: | 08/00331-9 - Utilização de coculturas microbianas para a produção e descoberta de produtos naturais bioativos |
| Beneficiário: | Miriam Harumi Kossuga |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 10/50190-2 - Investigação do potencial biotecnológico e metabólico de organismos marinhos para processos de biorremediação e produção de substâncias com atividades anti-virais, anti-leishmania e anti-inflamatória (Biodiversidade Marinha) |
| Beneficiário: | Roberto Gomes de Souza Berlinck |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |