Role of alpha(2)-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis

Autor(es)

Andrade, C. A. F. ; Andrade-Franze, G. M. F. ; De Paula, P. M. ; De Luca, L. A., Jr. ; Menani, J. V.

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 47, n. 1, p. 8-pg., 2014-01-01.

Resumo

Central alpha(2)-adrenoceptors and the pontine lateral parabrachial nucleus (LPBN) are involved in the control of sodium and water intake. Bilateral injections of moxonidine (alpha(2)-adrenergic/imidazoline receptor agonist) or noradrenaline into the LPBN strongly increases 0.3 M NaCl intake induced by a combined treatment of furosemide plus captopril. Injection of moxonidine into the LPBN also increases hypertonic NaCl and water intake and reduces oxytocin secretion, urinary sodium, and water excreted by cell-dehydrated rats, causing a positive sodium and water balance, which suggests that moxonidine injected into the LPBN deactivates mechanisms that restrain body fluid volume expansion. Pretreatment with specific alpha(2)-adrenoceptor antagonists injected into the LPBN abolishes the behavioral and renal effects of moxonidine or noradrenaline injected into the same area, suggesting that these effects depend on activation of LPBN alpha(2)-adrenoceptors. In fluid-depleted rats, the palatability of sodium is reduced by ingestion of hypertonic NaCl, limiting intake. However, in rats treated with moxonidine injected into the LPBN, the NaCl palatability remains high, even after ingestion of significant amounts of 0.3 M NaCl. The changes in behavioral and renal responses produced by activation of alpha(2)-adrenoceptors in the LPBN are probably a consequence of reduction of oxytocin secretion and blockade of inhibitory signals that affect sodium palatability. In this review, a model is proposed to show how activation of alpha(2)-adrenoceptors in the LPBN may affect palatability and, consequently, ingestion of sodium as well as renal sodium excretion. (AU)

• Processo FAPESP: 12/01955-1 - Avanços no estudo do núcleo parabraquial lateral e do núcleo do trato solitário rostral na palatabilidade ao sódio hipertônico e controle do equilíbrio hidroeletrolítico
• Beneficiário: Carina Aparecida Fabrício de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular