Hypothalamic inflammation and the central nervous system control of energy homeostasis

Autor(es)

Pimentel, Gustavo D. ; Ganeshan, Kirthana ; Carvalheira, Jose B. C.

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 397, n. 1-2, p. 8-pg., 2014-11-25.

Resumo

The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 13/01649-0 - Caracterização da AMPK hipotalâmica no desenvolvimento tumoral e no processo inflamatório central e sistêmico em roedores
• Beneficiário: Gustavo Duarte Pimentel
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 11/02806-7 - Caracterização da da AMPK/mTOR hipotalâmica na anorexia induzida pelo câncer
• Beneficiário: Gustavo Duarte Pimentel
• Modalidade de apoio: Bolsas no Brasil - Doutorado