Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up

Autor(es)

Dias Goncalves, Tiago Eduardo ; Santos Zimmermann, Glaucia ; Cristina Figueiredo, Luciene ; de Carvalho Souza, Monique ; Ferreira da Cruz, Daniele ; Ferreira Bastos, Marta ; Pereira da Silva, Helio Doyle ; Mendes Duarte, Poliana

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 42, n. 5, p. 9-pg., 2015-05-01.

Resumo

AimThis study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) and serum levels of adipokines in patients with chronic periodontitis (CP) with or without obesity. MethodsTwenty patients with obesity and 20 patients without obesity, all with CP, received SRP. Serum and GCF levels of resistin, adiponectin, leptin, tumour necrosis factor [TNF]- and interleukin [IL]-6 were evaluated by enzyme-linked immunosorbent assay at baseline, 3, 6 and 12months post-therapy. ResultsSRP reduced the amounts of TNF- in deep sites and increased the concentration of adiponectin in shallow sites of non-obese patients (p<0.05). SRP increased the concentrations of TNF- and leptin in patients with obesity (p<0.05). GCF levels of TNF- were higher in patients with obesity than in patients without obesity at all time-points (p<0.05). There were no changes in serum levels of any adipokines for any group after therapy (p>0.05). Patients with obesity exhibited higher serum levels of leptin at all time-points and IL-6 at 3months post-therapy (p<0.05). ConclusionsObesity may modulate systemic and periodontal levels of adipokines in favour of pro-inflammation, independently of periodontal therapy. SRP did not affect the circulating levels of adipokines in patients with or without obesity. (AU)

• Processo FAPESP: 11/14875-3 - Efeitos da terapia periodontal básica nos parâmetros clínicos e níveis de adipocitocinas em indivíduos obesos com periodontite crônica
• Beneficiário: Tiago Eduardo Dias Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/01072-5 - Metronidazol e amoxicilina sistêmicos adjunto à raspagem e alisamento radicular no tratamento de periodontite crônica em diabéticos tipo 2: avaliações clínicas, glicêmicas e microbiológicas
• Beneficiário: Poliana Mendes Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular