| Texto completo | |
| Autor(es): Mostrar menos - |
Oliveira, Denise Tostes
;
Bravo-Calderon, Diego Mauricio
;
Lauand, Gustavo Amaral
;
Assao, Agnes
;
Suarez-Penaranda, Jose-Manuel
;
Perez-Sayans, Mario
;
Garcia-Garcia, Abel
;
Marana, Aparecido Nilceu
;
Nonogaki, Suely
;
Pereira Lauris, Jose Roberto
;
Kowalski, Luiz Paulo
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ONCOLOGY; v. 2016, p. 8-pg., 2016-01-01. |
| Resumo | |
Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (beta 2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with beta 2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of beta 2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of beta 2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (p = 0.383; p = 0.002). The immunohistochemical distribution of beta 2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of beta 2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive. (AU) | |
| Processo FAPESP: | 11/11630-0 - Comparação do receptor beta-2-adrenérgico na mucosa bucal de margens cirúrgicas e nas células malignas do carcinoma espinocelular de boca |
| Beneficiário: | Gustavo Amaral Lauand |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 12/04098-2 - Expressão do receptor beta-2 adrenérgico nos tecidos a fresco de carcinomas espinocelulares de boca |
| Beneficiário: | Gustavo Amaral Lauand |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica |