| Texto completo | |
| Autor(es): |
Urbinati, Ismael
;
Stafuzza, Nedenia Bonvino
;
Oliveira, Marcos Tulio
;
Seleguim Chud, Tatiane Cristina
;
Higa, Roberto Hiroshi
;
de Almeida Regitano, Luciana Correia
;
de Alencar, Mauricio Mello
;
Buzanskas, Marcos Eli
;
Munari, Danisio Prado
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY; v. 7, p. 9-pg., 2016-05-05. |
| Resumo | |
Background: Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism (SNP) panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures (SS). The SS are detectable by different methods, such as the extended haplotype homozygosity (EHH); and the integrated haplotype score (iHS), which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle (composite breed), genotyped with high-density SNP panel. Results: A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The iHS statistic for each marker was transformed into piHS for better interpretation of the results. Chromosomes BTA5 and BTA14 showed piHS > 5, with 39 and nine statistically significant SNPs (P < 0.00001), respectively. For the candidate selection regions, iHS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism, melanin biosynthesis (pigmentation), and embryonic and bone development. Conclusions: The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds (i.e. Charolais), are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be associated with Canchim characterization. (AU) | |
| Processo FAPESP: | 14/02253-6 - Investigando as alterações metabólicas causadas pela expressão transgênica da oxidase alternativa mitocondrial de Ciona intestinalis em Drosophila melanogaster |
| Beneficiário: | Marcos Túlio de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 13/09050-0 - Assinaturas de seleção em bovinos da raça Canchim |
| Beneficiário: | Ismael Urbinati |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 15/08939-0 - Identificação de regiões com variações no número de cópias dos segmentos de DNA em bovinos da raça Girolando |
| Beneficiário: | Tatiane Cristina Seleguim Chud |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/19335-2 - Estudo do nível de mistura em animais da raça Canchim e grupo genético ma utilizando painel de polimorfismos de nucleotídeo único de alta densidade |
| Beneficiário: | Marcos Eli Buzanskas |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |