Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects

Autor(es)

Cartolano, Flavia De C. ; Dias, Gabriela D. ; de Freitas, Maria C. P. ; Figueiredo Neto, Antonio M. ; Damasceno, Nagila R. T.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DIABETES RESEARCH; v. 2017, p. 8-pg., 2017-01-01.

Resumo

Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. The impact of IR as a predictor of atherogenic lipoproteins was tested by logistic regression analysis in raw and adjusted models. Results. HDL-C and Apo AI were significantly lower in individuals with IR. Individuals with IR had a higher percentage of small HDL particles, lower percentage in the larger ones, and reduced frequency of phenotype A (IR = 62%; non-IR = 83%). IR individuals had reduced probability to have large HDL (OR = 0.213; CI = 0.999-0.457) and had twice more chances to show increased small HDL (OR = 2.486; CI = 1.341-7.051). IR was a significant predictor of small LDL (OR = 3.075; CI = 1.341-7.051) and atherogenic phenotype (OR = 3.176; CI = 1.469-6.867). Conclusion. IR, previously DM2 diagnosis, is a strong predictor of quantitative and qualitative features of lipoproteins directly associated with an increased atherogenic risk. (AU)

• Processo FAPESP: 08/57685-7 - Instituto Nacional de Ciência e Tecnologia de Fluídos Complexos
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/06222-0 - Associação da leptina e adiponectina com a capacidade antioxidante da lipoproteína de alta densidade em indivíduos com Diabetes Mellitus
• Beneficiário: Gabriela Duarte Dias
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/13616-4 - Propriedades ópticas e estruturais de elastômeros e fluidos complexos de interesse biológico
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/12523-2 - Propriedades físico-químicas da LDL e da HDL, marcadores cardiometabólicos e oxidativos podem ser modulados pelo consumo de ômega-3, ômega-6 e ômega-9 em indivíduos adultos?
• Beneficiário: Nágila Raquel Teixeira Damasceno
• Modalidade de apoio: Auxílio à Pesquisa - Regular