| Texto completo | |
| Autor(es): |
Freitas, Patricia D.
;
Ferreira, Palmira G.
;
Silva, Aline G.
;
Stelmach, Rafael
;
Carvalho-Pinto, Regina M.
;
Fernandes, Frederico L. A.
;
Mancini, Marcia C.
;
Sato, Maria N.
;
Martins, Milton A.
;
Carvalho, Celso R. F.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | American Journal of Respiratory and Critical Care Medicine; v. 195, n. 1, p. 11-pg., 2017-01-01. |
| Resumo | |
Rationale: Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. Objectives: To examine the effect of exercise training in a weight loss program on asthma control, quality of life, inflammatory biomarkers, and lung function. Methods: Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program plus exercise (WL + E group, n = 28) or a weight-loss program plus sham (WL + S group, n = 27), where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL + E group incorporated aerobic and resistance muscle training, whereas the WL + S group incorporated breathing and stretching exercises. Measurements and Main Results: The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength, and inflammatory/antiinflammatory biomarkers. After 3 months, 51 patients were analyzed. Compared with the WL + S group, the WL + E group demonstrated improved clinical control scores (median [25th to 75th percentile],-0.7 [-1.3 to -0.3] vs. -0.3 [-0.9 to 0.4]; P = 0.01) and greater weight loss (mean +/- SD, -6.8% +/- 3.5 vs. -3.1% +/- 2.6; P < 0.001) and aerobic capacity (median [25th to 75th percentile], 3.0 [2.4 to 4.0] vs. 0.9 [-0.3 to 1.3] ml O-2 X kg(-1) X min(-1); P < 0.001). These improvements in the WL + E group were also accompanied by improvements in lung function, antiinflammatory biomarkers, and vitamin D levels, as well as reductions in airway and systemic inflammation. Conclusions: Adding exercise to a short-term weight-loss program should be considered as a useful strategy for achieving clinical control of asthma in obese patients. (AU) | |
| Processo FAPESP: | 12/16134-3 - Efeitos de um programa de exercício físico no controle clínico e nos fatores de saúde relacionados à qualidade de vida em asmáticos obesos |
| Beneficiário: | Patricia Duarte Freitas |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 12/16700-9 - Análise dos fatores limitantes do exercício e efeitos de um programa de exercício físico no controle clínico e nos fatores de saúde relacionados à qualidade de vida em asmáticos obesos |
| Beneficiário: | Celso Ricardo Fernandes de Carvalho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |