Near future of tumor immunology: Anticipating resistance mechanisms to immunotherapies, a big challenge for clinical trials

Autor(es)

Portela Catani, Joao Paulo ; Riechelmann, Rachel P. ; Adjemian, Sandy ; Strauss, Bryan E.

• Tipo de documento: Artigo Científico
• Fonte: HUMAN VACCINES & IMMUNOTHERAPEUTICS; v. 13, n. 5, p. 3-pg., 2017-01-01.

Resumo

The success of immunotherapies brings hope for the future of cancer treatment. Even so, we are faced with a new challenge, that of understanding which patients will respond initially and, possibly, develop resistance. The examination of the immune profile, especially approaches related to the immunoscore, may foretell which tumors will have a positive initial response. Ideally, the mutation load would also be analyzed, helping to reveal tumor associated antigens that are predictive of an effective cytolytic attack. However, the response may be hindered by changes induced in the tumor and its microenvironment during treatment, perhaps stemming from the therapy itself. To monitor such alterations, we suggest that minimally invasive approaches should be explored, such as the analysis of circulating tumor DNA. When testing new drugs, the data collected from each patient would initially represent an N of 1 clinical trial that could then be deposited in large databases and mined retrospectively for trends and correlations between genetic alterations and response to therapy. We expect that the investment in personalized approaches that couple molecular analysis during clinical trials will yield critical data that, in the future, may be used to predict the outcome of novel immunotherapies. (AU)

• Processo FAPESP: 14/11524-3 - Investigação dos mecanismos da resposta imune antitumoral induzida pela transferência gênica combinada de p19Arf e interferon-beta - ensaios em um modelo murino de câncer de pulmão
• Beneficiário: João Paulo Portela Catani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/25380-8 - Análise da expressão gênica global regulada pelo complexo prame/ezh2 como ferramenta para descoberta de novos alvos terapêuticos contra o câncer
• Beneficiário: Sandy Adjemian Portela Catani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/25167-5 - Transferência gênica de p19Arf e interferon-beta: delineando a importância de sua combinação em modelos murinos de terapia gênica do câncer
• Beneficiário: Bryan Eric Strauss
• Modalidade de apoio: Auxílio à Pesquisa - Regular