Effects of periodontal treatment on primary sjogren's syndrome symptoms

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Batitucci Ambrosio, Lucas Macedo ; Rovai, Emanuel da Silva ; de Franca, Bruno Nunes ; Balzarini, Danilo Andres ; Abreu, Ieda Santos ; Bologna Lopes, Sheyla Batista ; Nunes, Thais Borguezan ; Lourenco, Silvia Vanessa ; Pasoto, Sandra Gofinet ; Saraiva, Luciana ; Holzhausen, Marinella

• Tipo de documento: Artigo Científico
• Fonte: BRAZILIAN ORAL RESEARCH; v. 31, p. 12-pg., 2017-01-01.

Resumo

The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjogren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1 beta, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients. (AU)

• Processo FAPESP: 13/26381-0 - Análise de citocinas (no fluido gengival e no soro) e de patógenos periodontais (Aggregatibacter actinomycetemcomitans, Porphyromonas Gingivalis, Tannerella forsythia e Treponema denticola) de pacientes com periodontite agressiva. estudo longitudinal
• Beneficiário: Luciana Saraiva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/07396-2 - Efeito da ativação do receptor ativado por protease do tipo 1 (PAR1) sobre a atividade osteogênica de células do ligamento periodontal
• Beneficiário: Marinella Holzhausen Caldeira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/06387-7 - Expressão do receptor ativado por protease tipo 2 (PAR-2) em células do fluido gengival de pacientes diabéticos do tipo 2
• Beneficiário: Bruno Nunes de França
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica