Talarazines A-E: Noncytotoxic Iron(III) Chelators from an Australian Mud Dauber Wasp-Associated Fungus, Talaromyces sp (CMB-W045)

Autor(es)

Kalansuriya, Pabasara ; Quezada, Michelle ; Esposito, Breno P. ; Capon, Robert J.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 80, n. 3, p. 7-pg., 2017-03-01.

Resumo

Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A-E (1-5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3 Marfey's method. We report on the noncytotoxic Fe(III) chelation properties of 1-8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe(III) binding metabolites (i.e., 8) from complex extracts. (AU)

• Processo FAPESP: 13/13166-4 - Bioprospecção de sideróforos marinhos com vistas à terapia de quelação de sobrecarga de ferro
• Beneficiário: Breno Pannia Esposito
• Modalidade de apoio: Bolsas no Exterior - Pesquisa