Intrauterine exposure to oestradiol promotes sex-specific differential effects on the prostatic development of neonate gerbils

Autor(es)

Sanches, Bruno D. A. ; Maldarine, Juliana S. ; Biancardi, Manoel F. ; Santos, Fernanda C. A. ; Pinto-Fochi, Maria E. ; Antoniassi, Julia Q. ; Goes, Rejane M. ; Vilamaior, Patricia S. L. ; Taboga, Sebastiao R.

• Tipo de documento: Artigo Científico
• Fonte: Cell Biology International; v. 41, n. 11, p. 10-pg., 2017-11-01.

Resumo

The effects of intrauterine exposure to 17 beta-oestradiol (E2) are well studied for the male prostate and there are accumulating evidences that the exposure to high dosages leads to a hypomorphic development. However, there is a lack of information about the effects of intrauterine exposure to E2 in the prostate of rodent females, and such research becomes relevant in view of the presence of functional prostate in a proportion of women, and the morphophysiological similarities between the prostate of female rodents and the prostate of women. This study uses histochemical, immunohistochemical, immunofluorescence and three-dimensional (3D) reconstruction techniques to evaluate the effects of intrauterine exposure to E2 (500 BW/d) on neonatal prostate development in both male and female gerbils. It was verified that intrauterine exposure to E2 promotes epithelial proliferation and growth of prostatic budding in females, whereas in males the prostatic budding shows hypomorphic growth in the VMP (Ventral Mesenchymal Pad) as well as reduced epithelial proliferation. Together, the data demonstrate that intrauterine exposure to E2 causes different effects on male and female prostates of the gerbil even at the early postnatal development of the gland. (AU)

• Processo FAPESP: 13/16443-9 - Estudo descritivo do processo de ramificação do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Bruno Casagrande Zani
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/15939-0 - Avaliação da exposição estrogênica intra-uterina sobre as principais vias de interações epitélio-mesenquimais envolvidas na morfogênese das ramificações do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Bruno Domingos Azevedo Sanches
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto