Interplay of activation kinetics and the derivative conductance determines resonance properties of neurons

Autor(es)

Pena, Rodrigo F. O. ; Ceballos, Cesar C. ; Lima, Vinicius ; Roque, Antonio C.

• Tipo de documento: Artigo Científico
• Fonte: PHYSICAL REVIEW E; v. 97, n. 4, p. 10-pg., 2018-04-10.

Resumo

In a neuron with hyperpolarization activated current (I-h), the correct input frequency leads to an enhancement of the output response. This behavior is known as resonance and is well described by the neuronal impedance. In a simple neuron model we derive equations for the neuron's resonance and we link its frequency and existence with the biophysical properties of I-h. For a small voltage change, the component of the ratio of current change to voltage change (dI/dV) due to the voltage-dependent conductance change (dg/dV) is known as derivative conductance (G(h)(Der)). We show that both G(h)(Der) and the current activation kinetics (characterized by the activation time constant tau(h)) are mainly responsible for controlling the frequency and existence of resonance. The increment of both factors (G(h)(Der) and tau(h)) greatly contributes to the appearance of resonance. We also demonstrate that resonance is voltage dependent due to the voltage dependence of G(h)(Der). Our results have important implications and can be used to predict and explain resonance properties of neurons with the I-h current. (AU)

• Processo FAPESP: 17/05874-0 - Modelos de redes neurais com neurônios estocásticos e diferentes topologias: construção e análise
• Beneficiário: Vinícius Lima Cordeiro
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/50122-0 - Fenômenos dinâmicos em redes complexas: fundamentos e aplicações
• Beneficiário: Elbert Einstein Nehrer Macau
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/25667-8 - Mecanismos de propagação de atividade epileptiforme em um modelo cortical de grande porte
• Beneficiário: Rodrigo Felipe de Oliveira Pena
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto