| Texto completo | |
| Autor(es): |
da Silveira Campos, Raquel Munhoz
;
Landi Masquio, Deborah Cristina
;
Corgosinho, Flavia Campos
;
de Carvalho-Ferreira, Joana Pereira
;
Netto, Barbara Dal Molin
;
Grotti Clemente, Ana Paula
;
Tock, Lian
;
Tufik, Sergio
;
de Mello, Marco Tulio
;
Damaso, Ana Raimunda
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 62, n. 3, p. 10-pg., 2018-05-01. |
| Resumo | |
Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice. Arch Endocrinol Metab. 2018;62(3):275-84 (AU) | |
| Processo FAPESP: | 15/14309-9 - Efeitos do Exercício Físico associado à Fototerapia sobre os Marcadores da Adipogênese e Transdiferenciação do Tecido Adiposo em Mulheres Adultas com Obesidade |
| Beneficiário: | Raquel Munhoz da Silveira Campos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/19046-0 - Fototerapia e Exercício Físico Aeróbio: efeitos potenciais no papel da irisina e fatores anorexígenos e orexígenos |
| Beneficiário: | Marcela Sene Fiorese |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/08522-6 - Novas perspectivas terapêuticas na obesidade |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |