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Entree


Component mechanisms of executive function in schizophrenia and their contribution to functional outcomes

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Autor(es):
Berberian, Arthur A. ; Gadelha, Ary ; Dias, Natalia M. ; Mecca, Tatiana P. ; Comfort, William E. ; Bressan, Rodrigo A. ; Lacerda, Acioly T.
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Revista Brasileira de Psiquiatria; v. 41, n. 1, p. 9-pg., 2019-01-01.
Resumo

Objective: In schizophrenia, scores reflecting deficits in different cognitive processes are strongly correlated, making it difficult to establish a solid relationship between different cognitive mechanisms and other features of this disorder. The objective of this study was to explore whether three frequently postulated executive functions (updating, shifting, and inhibition) could be compared between groups and considered independently in terms of their respective roles in functional outcome. Methods: This study relied on confirmatory factor analysis of schizophrenia patients (n=141) and healthy controls (n=119). The main analyses examined the degree to which three executive functions (updating, set-shifting, and inhibition) could be separated in schizophrenia and compared this model among groups. Structural equation modeling analysis was also performed to examine the extent to which executive function components contribute to functional outcome in schizophrenia. Results: Multiple-group confirmatory factor analysis with unconstrained model parameters indicated that the full three-factor model may fit the data in both groups (chi(2)=61.48, degrees of freedom=34, p < 0.001, comparative fit index=0.95; standardized root mean square residual=0.037; root mean square error of approximation=0.04; Akaike's information criteria=169.49; normed fit index=0.90), although there was also a good data fit for the patient group with a two-factor model. In the patient group, structural equation modeling suggested that shifting and (principally) updating were associated with the general measure of functional outcome (regression path coefficients: 0.34, p < 0.005; 0.39, p < 0.005, respectively), although when combined the mechanisms fail to contribute. Conclusion: This data suggests that the factor structure may be similar but not identical between groups, and both updating and shifting may play an important role in functional outcome in schizophrenia. (AU)

Processo FAPESP: 11/50740-5 - Prevenção na esquizofrenia e no transtorno bipolar da neurociência à comunidade: uma plataforma multifásica, multimodal e translacional para investigação e intervenção
Beneficiário:Rodrigo Affonseca Bressan
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 07/58630-9 - Avaliacao de perfis de funcoes executivas em pacientes esquizofrenicos.
Beneficiário:Arthur de Almeida Berberian
Modalidade de apoio: Bolsas no Brasil - Doutorado