Epigenetic alterations in salivary gland tumors

Autor(es)

dos Santos, Erison S. ; Ramos, Joab C. ; Normando, Ana Gabriela C. ; Mariano, Fernanda, V ; Paes Leme, Adriana F.

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 26, n. 8, p. 9-pg., 2020-01-22.

Resumo

Salivary gland tumors (SGTs) comprise a heterogeneous group of benign and malignant neoplasms that exhibit significant variability in their microscopic appearance, clinical presentation, and biological behavior. The etiologic factors are unknown; however, chromosomic translocation, secondary radiation, and chemotherapy can be associated with the development of SGT. It has been indicated that epigenetic alterations can be responsible for the development and progress of these neoplasms. The epigenetic mechanisms are defined as a set of DNA changes that do not alter the sequence of nucleotide bases but alter the expression of the proteins. These alterations have been studied in the SGT, and they were associated with the development and progress of these neoplasms and may influence on SGT prognosis. Hence, we critically review the currently available data on the participation of epigenetic events on salivary gland tumors. (AU)

• Processo FAPESP: 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/00831-0 - Estudo das alterações genéticase metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 18/19922-9 - Análise proteômica dos fluidos lacrimais em pacientes com lesões orais potencialmente malignas e câncer de boca
• Beneficiário: Erison Santana dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado