Marrow Adipocytes: Origin, Structure, and Function

Autor(es)

de Paula, Francisco J. A. ; Rosen, Clifford J. ; Nelson, MT ; Walsh, K

• Tipo de documento: Artigo Científico
• Fonte: ANNUAL REVIEW OF PHYSIOLOGY, VOL 82; v. 82, p. 24-pg., 2020-01-01.

Resumo

The skeleton harbors an array of lineage cells that have an essential role in whole body homeostasis. Adipocytes start the colonization of marrow space early in postnatal life, expanding progressively and influencing other components of the bone marrow through paracrine signaling. In this unique, closed, and hypoxic environment close to the endosteal surface and adjacent to the microvascular space the marrow adipocyte can store or provide energy, secrete adipokines, and target neighboring bone cells. Adipocyte progenitors can also migrate from the bone marrow to populate white adipose tissue, a process that accelerates during weight gain. The marrow adipocyte also has an endocrine role in whole body homeostasis through its varied secretome that targets distant adipose depots, skeletal muscle, and the nervous system. Further insights into the biology of this unique and versatile cell will undoubtedly lead to novel therapeutic approaches to metabolic and age-related disorders such as osteoporosis and diabetes mellitus. (AU)

• Processo FAPESP: 18/14060-9 - Aplicação da ressonância magnética para estudo quantitativo da microarquitetura óssea e sua relação com o acúmulo de gordura muscular e óssea no diabetes melito tipo 2
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular