Regulatory T cells isolated from endometriotic peritoneal fluid express a different number of Toll-like receptors

Autor(es)

Hernandes, Camila ; Gueuvoghlanian-Silva, Barbara Yasmin ; Monnaka, Vitor Ulisses ; Ribeiro, Natalia Mazini ; Pereira, Welbert de Oliveira ; Podgaec, Sergio

• Tipo de documento: Artigo Científico
• Fonte: Einstein (São Paulo); v. 18, p. 6-pg., 2020-01-01.

Resumo

Objective: To analyze and compare the expression of Toll-like receptors by regulatory T cells present in the peritoneal fluid of patients with and without endometriosis. Methods: Regulatory T cells were isolated from peritoneal fluid of women with and without endometriosis, collected during surgery, and mRNA was extracted for analysis of Toll-like receptors expression by reverse-transcriptase polymerase chain reaction. Results: Patients with endometriosis presented regulatory T cells expressing a larger number and variety of Toll-like receptors when compared to regulatory T cells from patients in the Control Group. Toll-like receptor-1 and Toll-like receptor-2 in regulatory T cells were expressed in both groups. All other expressed Toll-like receptors types were only found in regulatory T cells from the Endometriosis Group. Conclusion: Patients with endometriosis had peritoneal regulatory T cells expressing various Toll-like receptors types. (AU)

• Processo FAPESP: 14/08227-7 - Ativação das células T reguladoras na endometriose profunda
• Beneficiário: Bárbara Yasmin Gueuvoghlanian Silva Lopes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/27092-2 - Ativação das células T reguladoras na endometriose profunda
• Beneficiário: Sérgio Podgaec
• Modalidade de apoio: Auxílio à Pesquisa - Regular