Recent advances in catalytic enantioselective multicomponent reactions

Autor(es)

Nunes, Paulo Sergio Goncalves ; Vidal, Herika Danielle Almeida ; Correa, Arlene G.

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 18, n. 39, p. 23-pg., 2020-10-21.

Resumo

Multicomponent reactions (MCRs) undoubtedly correspond to one of the synthetic strategies that best fit the new demands of chemistry for presenting high atom economy and enabling molecular diversity. However, many challenges still exist when products possessing stereogenic centres are formed. The field of asymmetric catalytic reactions has achieved significant progress in recent decades; new applications for chiral ligands and catalysts have been demonstrated and new catalysts have been specifically designed for challenging chemical conversions. In this sense, highly efficient approaches for classic multicomponent reactions such as the Ugi reaction and a number of new asymmetric MCRs have been described. In this review we discuss the recent developments that enable catalytic enantioselective MCRs including the proposed mechanistic pathways. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 19/06555-0 - Reações one-pot de Adição de Michael organocatalisada e multicomponentes
• Beneficiário: Paulo Sérgio Gonçalves Nunes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado