Blue light-promoted N-H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates: Synthesis of unnatural alpha-aryl amino acid derivatives

Autor(es)

Okada Jr, Celso Y. ; dos Santos, Caio Y. ; Jurberg, Igor D.

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron; v. 76, n. 51, p. 10-pg., 2020-12-18.

Resumo

A photochemical protocol using blue light allows the N-H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates to afford the corresponding alpha-amino esters. This method is experimentally simple, inexpensive and tolerates numerous functional groups, thus allowing the straightforward preparation of a variety of alpha-aryl amino acid derivatives in good yields. (C) 2020 Published by Elsevier Ltd. (AU)

• Processo FAPESP: 17/24017-0 - Aplicação de Isoxazolonas em Síntese Orgânica
• Beneficiário: Igor Dias Jurberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular