Studies of the Electrochemical Degradation of Acetaminophen Using a Real-Time Biomimetic Sensor

Autor(es)

Quintino de Oliveira, Mariana Calora ^[1] ; Tanaka, Auro Atsushi ^[2] ; Roberto de Vasconce los Lanza, Marcos ^[3] ; Taboada Sotomayor, Maria Del Pilar ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Sao Paulo UNESP, Dept Analyt Chem, Inst Chem, BR-14801970 Araraquara, SP - Brazil

^[2] Fed Univ Maranhao UFMA, Ctr Phys Sci & Technol, BR-65085580 Sao Luis, MA - Brazil

^[3] Univ Sao Paulo, Dept Mol Phys Chem IQSC, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 23, n. 11, p. 2616-2621, NOV 2011.
• Citações Web of Science: 2

Resumo

Real-time monitoring of the electrochemical degradation of acetaminophen was performed using a biomimetic sensor coupled to a flow injection analysis (FIA) system. Degradation of the drug was carried out at constant current density (24 to 180 mAcm(-2)) in an electrolyte consisting of 0.1 molL(-1) K(2)SO(4)/5.0 x 10(-4) molL(-1) FeSO(4)center dot 7H(2)O. Two commercial DSA anodes (DSA-Cl(2) and DSA-O(2)) were compared. The degradation process was monitored online using an amperometric sensor based on the biomimetic catalyst iron(III) tetrapyridinoporphyrazine (FeTPyPz), coupled to the degradation cell. The optimized FIA detection system employed the electrolyte solution as carrier, a flow rate of 1.25 mLmin(-1) and an injected sample volume of 75 mu L. The real-time data obtained showed, as expected, that acetaminophen degradation followed pseudo-first order kinetics, with the DSA-Cl(2) anode showing a higher efficiency according to the calculated apparent rate constant values. The advantage of the proposed on-line system is that a larger number of points can be monitored in a shorter time compared to other off-line methods, which improves the accuracy of estimates of electrochemical degradation constants. (AU)

• Processo FAPESP: 08/00303-5 - Construção de sensores biomiméticos para determinação de fármacos e seu acoplamento a sistemas em fluxo
• Beneficiário: Maria Del Pilar Taboada Sotomayor
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/08314-3 - Degradação de pesticidas organofosforados (clorpirifós, paration-metílico e profenofós) via processos eletroquímicos / processos oxidativos avançados
• Beneficiário: Marcos Roberto de Vasconcelos Lanza
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/05899-3 - Acoplamento de um Sensor Biomimético com um Reator Eletroquímico para Monitoramento "on line" da Degradação Eletroquímica de Paracetamol
• Beneficiário: Mariana Calora Quintino de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica