The Impact of Gastric Bypass on Telomere Length and Shelterin Complex Gene Expression: 6 Months Prospective Study

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Welendorf, Caroline Rossi ; Nicoletti, Carolina Ferreira ; Noronha, Natalia Yumi ; Ferreira, Flavia Campos ; Wolf, Leticia Santana ; de Souza Pinhel, Marcela Augusta ; Pinhanelli, Vitor Caressato ; de Oliveira, Cristiana Cortes ; de Oliveira, Bruno Affonso Parenti ; dos Santos Martins, Luzania ; Junior, Wilson Salgado ; Nonino, Carla Barbosa

• Tipo de documento: Artigo Científico
• Fonte: OBESITY SURGERY; v. 31, n. 6, p. 8-pg., 2021-03-18.

Resumo

BackgroundTelomeres are structures located at the ends of chromosomes associated with a protein complex, known as the shelterin complex. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. In this context, bariatric surgery is one of the most effective treatment modalities in improving metabolic control.AimTherefore, the present study aimed to evaluate how a short postoperative period of gastric bypass affects TL and expression of POT1, TRF1 and TRF2 genes.MethodsForty-eight women submitted to RYGB were evaluated before and after 6 months of the surgical procedure. Anthropometric measures of body weight and height (BMI), abdominal circumference (AC), body composition, food intake and blood collection for biochemical evaluation, TL analysis (DNA), and gene expression (RNA) were collected at each moment.ResultsThere was a reduction of weight, BMI, AC, FM and FFM as well as of glycemia, total cholesterol, LDL-cholesterol, and triglycerides after gastric bypass. No difference in energy intake and macronutrients consumption was observed. There was no significant change in TL, but there was a significant increase of POT1 and TRF1 gene expression after surgery, while TRF2 expression did not change.ConclusionsDespite bariatric surgery is not capable of increasing telomere length in a short-term period, no reduction is observed; additionally, we found a correlation between serum triglycerides concentration and TL. The increase of POT1 and TRF1 gene expression may explain the maintenance of the TL after 6 months postoperative period. (AU)

• Processo FAPESP: 18/08784-4 - Reganho de peso no pós-operatório de cirurgia bariátrica: contribuições sociodemográficas, clínicas, nutricionais e genéticas
• Beneficiário: Carla Barbosa Nonino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua
• Beneficiário: Fernando Barbosa Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Temático