Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis

Autor(es)

Dos Santos, Erison Santana ; Normando, Ana Gabriela Costa ; Scarini, Joao Figueira ; Crescencio, Livia Ramalho ; de Lima-Souza, Reydson Alcides ; Mariano, Fernanda Viviane ; Leme, Adriana Franco Paes

• Tipo de documento: Artigo Científico
• Fonte: ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG; v. 25, n. 4, p. 12-pg., 2021-03-05.

Resumo

Purpose Different levels of miRNA expression have been described in salivary gland tumors as a potential diagnostic marker and predictor of survival. We systematically reviewed the literature to assess the diagnostic and prognostic value of miRNAs on salivary gland tumors. Methods An electronic search was conducted in PubMed, Scopus, Embase, Cochrane, and Web of Science databases. In the meta-analysis, we assumed random-effects model with adjusted hazard ratio (HR) and 95% confidence intervals (95% CI). For prognostic studies, the risk of bias was assessed by Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) and Quality Assessment Tool for Diagnostic Accuracy Studies-2 (QUADAS-2) was utilized for diagnostic studies. Results Gathered data from 1.131 patients in seven studies demonstrated that different levels of miRNA expression presented diagnostic and prognostic in SGTs. The meta-analysis showed that altered miRNA expression were associated with shortened survival (HR, 2.35, 95% CI, 1.77-3.10, P < .00001). For diagnostic meta-analysis, the overall pooled results for specificity and sensibility were 0.87-0.97 (95% CI, 0.72-1) and 0.68-0.91 (95% CI, 0.51-0.96), respectively. Conclusion MicroRNAs may be useful in prognostication of patients with SGTs; however, the diagnostic value of miRNAs in SGTs is still limited. (AU)

• Processo FAPESP: 18/19922-9 - Análise proteômica dos fluidos lacrimais em pacientes com lesões orais potencialmente malignas e câncer de boca
• Beneficiário: Erison Santana dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/09692-9 - Validação de proteínas-alvo associadas à progressão de lesões potencialmente malignas para Câncer Oral
• Beneficiário: Ana Gabriela Costa Normando
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo
• Beneficiário: João Figueira Scarini
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/06809-2 - Análise de espectrometria de massa na transformação maligna do adenoma pleomorfo. correlação de dados com expressão gênica e exoma
• Beneficiário: Reydson Alcides de Lima Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado