Histo-blood group A is a risk factor for severe COVID-19

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Garibaldi, Pedro M. M. ; Oliveira, Luciana C. ; da Fonseca, Benedito A. ; Martins, Maria A. ; Miranda, Carlos H. ; Almado, Carlos E. L. ; Langhi, Dante M. ; Gilio, Renato N. ; Palma, Leonardo C. ; Gomes, Bruno B. M. ; Bottura, Camila ; Barrientto, Larissa C. ; Donadel, Camila D. ; Calado, Rodrigo T. ; De Santis, Gil C.

• Tipo de documento: Artigo Científico
• Fonte: Transfusion Medicine; v. 32, n. 3, p. 4-pg., 2021-06-03.

Resumo

Objectives Evaluate the impact of ABO histo-blood group type on COVID-19 severity. Background ABO histo-blood type has been associated with different outcomes in infectious diseases. It has also shown a higher proportion of type A patients with SARS-CoV-2. In this observational study, extracted from an ongoing clinical trial on the efficacy of convalescent plasma transfused in COVID-19 patients, we describe the impact of ABO blood type on the risk of developing severe COVID-19. Materials and Methods Seventy-two consecutive patients (37 type A, 23 type O, 11 type B, 1 type AB) with severe (respiratory failure) COVID-19 were included. Control group was composed of 160 individuals randomly selected from the same populational basis. Results Blood group A was overrepresented (51.39%) in the patient group in relation to the control group (30%), whereas blood group O was less represented (31.94%) in patient than in control group (48%). Odds ratio (A vs. O) was 2.581 (1.381-4.817), CI 95%; p = 0.004. Also, blood group A patients appeared to have more severe disease, given by the scores of the Sequential Organ Failure Assessment and Simplified Acute Physiologic Score 3 (p = 0.036 and p = 0.058, respectively). Conclusion Histo-blood type A is associated with a higher risk of developing severe COVID-19 in relation to blood type O. (AU)

• Processo FAPESP: 20/05367-3 - Uso de plasma de doador convalescente para tratar pacientes com infecção grave pelo SARS-CoV-2 (COVID-19)
• Beneficiário: Rodrigo do Tocantins Calado de Saloma Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular