| Texto completo | |
| Autor(es): |
Wajima, Carolina Sayuri
;
Pitol-Palin, Leticia
;
Batista, Fabio Roberto de Souza
;
dos Santos, Paulo Henrique
;
Matsushita, Doris Hissako
;
Okamoto, Roberta
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 14, n. 1, p. 11-pg., 2024-02-04. |
| Resumo | |
Type 2 diabetes interferes with bone remodeling mechanisms, requiring studies to reverse this damage, and resveratrol is a polyphenol with rich properties. This study aimed to characterize the long bone morphology and peri-implant biomechanics of normoglycemic and type 2 diabetic animals treated with resveratrol. Thirty-two male Wistar rats were used and divided into normoglycemic and diabetic with or without treatment. They had the installation of implants in the tibia and treatment with oral resveratrol within 45 days. Resveratrol was responsible for weight homeostasis and decreased glycemic levels in rats with type 2 diabetes. The three-point bending testing, resveratrol showed positive effects on the biomechanics of long bones, corroborating a more resistant bone in comparison to untreated diabetics. Micro-ct revealed how bone metabolism is affected by systemic disease, decreasing bone quality. The counter-torque of normoglycemic animals showed superior osseointegration to diabetes, with no differences in the administration of the polyphenol, showing the sovereignty of the deleterious effects of the disease when there is a tissue lesion and an inflammatory picture installed. Overall, resveratrol acted positively in the etiopathogenesis of type 2 diabetes and revealed positive effects on the strength of long bones. (AU) | |
| Processo FAPESP: | 19/01634-0 - Reparo perimplantar em ratos diabéticos tipo 2, tratados pela combinação da terapia fotodinâmica antimicrobiana e compostos polifenóis: caracterização biomecânica, histométrica, microtomográfica e molecular |
| Beneficiário: | Letícia Pitol Palin |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/19019-0 - Caracterização morfológica e funcional de ossos longos e biomecânica periimplantar em ratos diabéticos tipo 2 tratados com resveratrol |
| Beneficiário: | Carolina Sayuri Wajima |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |