Comprehensive analysis of contaminants in Brazilian infant formulas: Application of QuEChERS coupled with UHPLC-QqQ-MS/MS and suspect screening-unknown analysis by UHPLC-Q-Orbitrap-MS

Autor(es)

Galindo, Marcella Vitoria ; Lopez-Ruiz, Rosalia ; Oliveira, Wellington da Silva ; Godoy, Helena Teixeira ; Frenich, Antonia Garrido ; Romero-Gonzalez, Roberto

• Tipo de documento: Artigo Científico
• Fonte: Journal of Chromatography A; v. 1726, p. 12-pg., 2024-05-14.

Resumo

Infant formulas (IF) can contain harmful chemical substances, such as pesticides and mycotoxins, resulting from the contamination of raw materials and inputs used in the production chain, which can cause adverse effects to infants. Therefore, the quick, easy, cheap, effective, rugged, and safe (QuEChERS) methodology prior ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry (UHPL-QqQ-MS/MS) analysis was applied for the determination of 23 contaminants, in 30 samples of Brazilian IF. The method was validated in terms of limit of detection (0.2 to 0.4 mu g/kg), limits of quantification (1 and 10 mu g/kg), and recovery (64 % to 122 %); precision values, in terms of relative standard deviation (RSD), were <= 20 %. Fenitrothion, chlorpyrifos, and bifenthrin were the pesticides detected in the samples, but the values did not exceed the limit set by the European Union (EU), and ANVISA, and they were detected under their limits of quantification. Additionally, suspect screening and unknown analysis were conducted to tentatively identify 32 substances, including some compounds not covered in this study, such as pesticides, hormones, and veterinary drugs. Carbofuran was identified, confirmed and quantified in 10 % of the samples. (AU)

• Processo FAPESP: 21/02153-5 - Incidencia de bisfenol A, benzofenonas e hidrocarbonetos policíclicos aromáticos em leite humano: um estudo exploratório
• Beneficiário: Marcella Vitoria Galindo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/06633-4 - Desenvolvimento de um método multirresíduo para detecção simultânea de pesticidas e micotoxinas em fórmulas infantis
• Beneficiário: Marcella Vitoria Galindo
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado