| Texto completo | |
| Autor(es): |
Bergamo, Edmara T. P.
;
de Oliveira, Paula G. F. P.
;
Campos, Tiago M. B.
;
Bonfante, Estevam A.
;
Tovar, Nick
;
Boczar, Daniel
;
Nayak, Vasudev Vivekanand
;
Coelho, Paulo G.
;
Witek, Lukasz
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 112, n. 2, p. 13-pg., 2024-02-01. |
| Resumo | |
This in vivo study evaluated the bone healing response around endosteal implants with varying surface topography/chemistry in a preclinical, large transitional model induced with metabolic syndrome (MS) and type-2 diabetes mellitus (T2DM). Fifteen Gottingen minipigs were randomly distributed into two groups: (i) control (normal diet, n = 5) and (ii) O/MS (cafeteria diet for obesity induction, n = 10). Following obesity induction, five minipigs from the obese/metabolic syndrome (O/MS) group were further allocated, randomly, into the third experimental group: (iii) T2DM (cafeteria diet + streptozotocin). Implants with different surface topography/chemistry: (i) dual acid-etched (DAE) and (ii) nano-hydroxyapatite coating over the DAE surface (NANO), were placed into the right ilium of the subjects and allowed to heal for 4 weeks. Histomorphometric evaluation of bone-to-implant contact (%BIC) and bone area fraction occupancy (%BAFO) within implant threads were performed using histomicrographs. Implants with NANO surface presented significantly higher %BIC (similar to 26%) and %BAFO (similar to 35%) relative to implants with DAE surface (%BIC = similar to 14% and %BAFO = similar to 28%, p < .025). Data as a function of systemic condition presented significantly higher %BIC (similar to 28%) and %BAFO (similar to 42%) in the control group compared with the metabolically compromised groups (O/MS: %BIC = 14.35% and %BAFO = 26.24%, p < .021; T2DM: %BIC = 17.91% and %BAFO = 26.12%, p < .021) with no significant difference between O/MS and T2DM (p > .05). Statistical evaluation considering both factors demonstrated significantly higher %BIC and %BAFO for the NANO surface relative to DAE implant, independent of systemic condition (p < .05). The gain increase of %BIC and %BAFO for the NANO compared with DAE was more pronounced in O/MS and T2DM subjects. Osseointegration parameters were significantly reduced in metabolically compromised subjects compared with healthy subjects. Nanostructured hydroxyapatite-coated surfaces improved osseointegration relative to DAE, regardless of systemic condition. (AU) | |
| Processo FAPESP: | 12/19078-7 - Desenvolvimento e processamento de compósito de Al2O3-ZrO2 para próteses monolíticas CAD/CAM: efeito do envelhecimento na resistência à flexão biaxial |
| Beneficiário: | Estevam Augusto Bonfante |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/08693-1 - Compósitos experimentais à base de alumina e zircônia infiltrados por vidro: caracterização microestrutural e das propriedades ópticas e mecânicas. |
| Beneficiário: | Edmara Tatiely Pedroso Bergamo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/06730-7 - Rumo à zircônia sustentável reciclada a partir do descarte de usinagem e melhorada por infiltração graduada e ao desenvolvimento de blocos de zircônia multicamada resistentes, graduados, e não suscetíveis ao envelhecimento |
| Beneficiário: | Estevam Augusto Bonfante |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 21/08018-2 - Caracterização nanomecânica de compósitos ZTA e ATZ infiltrados por vidro |
| Beneficiário: | Edmara Tatiely Pedroso Bergamo |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |