| Texto completo | |
| Autor(es): Mostrar menos - |
Guimaraes, Jhefferson Barbosa
;
Rodrigues, Vanessa Fernandes
;
Pereira, Italo Sousa
;
Manso, Gabriel Martins da Costa
;
Elias-Oliveira, Jefferson
;
Leite, Jefferson Antonio
;
Waldetario, Mariana Camila Goncalves Miranda
;
de Oliveira, Sarah
;
Gomes, Arilson Bernardo dos Santos Pereira
;
Faria, Ana Maria Caetano
;
Ramos, Simone Gusmao
;
Bonato, Vania L. D.
;
Silva, Joao Santana
;
Vinolo, Marco Aurelio Ramirez
;
Sampaio, Ulliana Marques
;
Clerici, Maria Teresa Pedrosa Silva
;
Carlos, Daniela
Número total de Autores: 17
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| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Leukocyte Biology; v. 115, n. 3, p. 14-pg., 2023-11-21. |
| Resumo | |
Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affects T1D remains uncertain. Using a streptozotocin-induced (STZ) mouse model, we studied INU's protective effects. Remarkably, STZ + INU mice resisted T1D, with none developing the disease. They had lower blood glucose, reduced pancreatic inflammation, and normalized serum insulin compared with STZ + SD mice. STZ + INU mice also had enhanced mucus production, abundant Bifidobacterium, Clostridium cluster IV, Akkermansia muciniphila, and increased fecal butyrate. In cecal lymph nodes, we observed fewer CD4+Foxp3+ regulatory T cells expressing CCR4 and more Foxp3+CCR4+ cells in pancreatic islets, with higher CCL17 expression. This phenotype was absent in CCR4-deficient mice on INU. INU supplementation effectively protects against experimental T1D by recruiting CCR4+ regulatory T cells via CCL17 into the pancreas and altering the butyrate-producing microbiota. (AU) | |
| Processo FAPESP: | 19/13858-0 - Efeito da administração do Bifidobacterium longum, com ou sem o prebiótico inulina, na produção de AGCC e na imunorregulação do DM1 em modelo experimental |
| Beneficiário: | Jhefferson Barbosa Guimarães |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 18/14815-0 - Estudo do perfil do microbioma intestinal e do potencial terapêutico de estratégias de intervenção na imunopatogenia do Diabetes tipo 1 e 2 |
| Beneficiário: | Daniela Carlos Sartori |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |