Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol

Autor(es)

Salvio, Ana Gabriela ; Stringasci, Mirian ; Requena, Michelle B. ; Fregolenti, Bianca A. ; Medeiro, Maira Monique da Costa ; Santos, Rosilene Guedes ; Bagnato, Vanderlei Salvador

• Tipo de documento: Artigo Científico
• Fonte: Photodiagnosis and Photodynamic Therapy; v. 45, p. 3-pg., 2024-02-27.

Resumo

Significance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful. Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm2). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm2). Disease-free survival rate and pain score during irradiations were evaluated. Results: The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home. Conclusions: A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 22/10860-6 - O uso de microagulhas dissolvíveis contendo ácido aminolevulínico para terapia fotodinâmica
• Beneficiário: Michelle Barreto Requena
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 23/04209-3 - Microagulhas dissolvíveis para tratamentos de câncer de pele não melanoma e melanoma com PDT e SDT: estudos básicos e experimentos pré-clínicos
• Beneficiário: Michelle Barreto Requena
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado