| Texto completo | |
| Autor(es): |
Neupane, Sharmila
;
de Amorim, Marcelo Rodrigues
;
Skellam, Elizabeth
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Beilstein Journal of Organic Chemistry; v. 20, p. 10-pg., 2024-02-19. |
| Resumo | |
Several under -explored Aspergillus sp. produce intriguing heptapeptides containing a gamma-aminobutyric acid (GABA) residue with as yet unknown biological functions. In this study, a new GABA-containing heptapeptide - unguisin J (1) - along with known unguisin B (2) were isolated from a solid culture of Aspergillus heteromorphus CBS 117.55. The structure of compound 1 was elucidated by extensive 1D and 2D NMR spectroscopic analysis including HSQC, HMBC, COSY, and 2D NOESY as well as HRESIMS. The stereochemistry of 1 and 2 was determined by Marfey's method. A biosynthetic gene cluster (BGC) encoding unguisins B and J was compared to characterized BGCs in other Aspergillus sp. Since the unguisin family of heptapetides incorporate different amino acid residues at different positions of the peptide, the A and C domains of the UngA NRPS were analyzed in an attempt to understand the lack of substrate specificity observed. (AU) | |
| Processo FAPESP: | 22/15570-6 - Investigando a biossíntese de citocalasanas do fungo marinho Peroneutypa sp. M16 |
| Beneficiário: | Marcelo Rodrigues de Amorim |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |