| Texto completo | |
| Autor(es): Mostrar menos - |
de Oliveira, Andreia Silva
;
Convento, Marcia Bastos
;
Razvickas, Clara Versolato
;
Castino, Bianca
;
Leme, Ala Moana
;
Luiz, Rafael da Silva
;
da Silva, Wesley Henrique
;
da Gloria, Maria Aparecida
;
Guirao, Tatiana Pinotti
;
Bondan, Eduardo
;
Schor, Nestor
;
Borges, Fernanda Teixeira
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICALS; v. 16, n. 10, p. 12-pg., 2023-10-01. |
| Resumo | |
Mesenchymal stromal cells (MSCs) obtained from bone marrow are a promising tool for regenerative medicine, including kidney diseases. A step forward in MSCs studies is cellular conditioning through specific minerals and vitamins. The Omega-3 fatty acids (omega 3) are essential in regulating MSCs self-renewal, cell cycle, and survival. The omega 3 could act as a ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma). This study aimed to demonstrate that omega 3 supplementation in rats could lead to the up-regulation of PPAR-gamma in the MSCs. The next step was to compare the effects of these MSCs through allogeneic transplantation in rats subjected to unilateral ureteral obstruction (UUO). Independent of omega 3 supplementation in the diet of the rats, the MSCs in vitro conserved differentiation capability and phenotypic characteristics. Nevertheless, MSCs obtained from the rats supplemented with omega 3 stimulated an increase in the expression of PPAR-gamma. After allogeneic transplantation in rats subjected to UUO, the omega 3 supplementation in the rats enhanced some nephroprotective effects of the MSCs through a higher expression of antioxidant enzyme (SOD-1), anti-inflammatory marker (IL-10), and lower expression of the inflammatory marker (IL-6), and proteinuria. (AU) | |
| Processo FAPESP: | 10/52180-4 - Fisiopatologia e regeneração das lesões renais |
| Beneficiário: | Nestor Schor |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |