| Texto completo | |
| Autor(es): |
Pachane, Bianca Cruz
;
Selistre-de-Araujo, Heloisa S.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICINES; v. 12, n. 6, p. 13-pg., 2024-06-01. |
| Resumo | |
A relevant challenge for the treatment of patients with neoplasia is the development of resistance to chemo-, immune-, and radiotherapies. Although the causes of therapy resistance are poorly understood, evidence suggests it relies on compensatory mechanisms that cells develop to replace specific intracellular signaling that should be inactive after pharmacological inhibition. One such mechanism involves integrins, membrane receptors that connect cells to the extracellular matrix and have a crucial role in cell migration. The blockage of one specific type of integrin is frequently compensated by the overexpression of another integrin dimer, generally supporting cell adhesion and migration. In particular, integrin alpha v beta 3 is a key receptor involved in tumor resistance to treatments with tyrosine kinase inhibitors, immune checkpoint inhibitors, and radiotherapy; however, the specific inhibition of the alpha v beta 3 integrin is not enough to avoid tumor relapse. Here, we review the role of integrin alpha v beta 3 in tumor resistance to therapy and the mechanisms that have been proposed thus far. Despite our focus on the alpha v beta 3 integrin, it is important to note that other integrins have also been implicated in drug resistance and that the collaborative action between these receptors should not be neglected. (AU) | |
| Processo FAPESP: | 22/04146-9 - Interação interespecífica e mecanismos de absorção de vesículas extracelulares com tropismo para células B |
| Beneficiário: | Bianca Cruz Pachane |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 21/01983-4 - Influência de vesículas extracelulares hipóxicas na invasão celular e no microambiente tumoral do Câncer de Mama |
| Beneficiário: | Bianca Cruz Pachane |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/05149-9 - O papel de gelatinases de vesículas extracelulares na invasão de células tumorais em normóxia e hipóxia |
| Beneficiário: | Bianca Cruz Pachane |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |