Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

Autor(es):Mostrar menos -

Prado, Wagner L. ^[1] ; Oyama, Lila M. ^{[2, 1]} ; Lofrano-Prado, Mara C. ^[1] ; de Piano, Aline ^[1] ; Stella, Sergio G. ^[1] ; Nascimento, Claudia M. O. ^[1] ; Carnier, June ^[1] ; Caranti, Danielle A. ^[1] ; Tock, Lian ^[1] ; Tufik, Sergio ^[3] ; de Mello, Marco Tulio ^{[1, 3]} ; Damaso, Ana R. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Paulista Med Sch, Nutr Postgrad Program, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil

^[3] Univ Fed Sao Paulo, Paulista Med Sch, Dept Psychobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ADOLESCENT HEALTH; v. 49, n. 3, p. 300-305, SEP 2011.
• Citações Web of Science: 5

Resumo

Objective: The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein {[}AgRP], neuropeptide Y {[}NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone {[}alpha-MSH]), in obese adolescents. Methods: A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15-19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, alpha-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks). Results: At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p<.05). The multidisciplinary therapy decreased NPY and AgRP values and increased alpha-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy. Conclusions: We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents. (C) 2011 Society for Adolescent Health and Medicine. All rights reserved. (AU)

• Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
• Beneficiário: Ana Raimunda Dâmaso
• Modalidade de apoio: Auxílio à Pesquisa - Regular