| Texto completo | |
| Autor(es): Mostrar menos - |
Prado, Wagner L.
[1]
;
Oyama, Lila M.
[2, 1]
;
Lofrano-Prado, Mara C.
[1]
;
de Piano, Aline
[1]
;
Stella, Sergio G.
[1]
;
Nascimento, Claudia M. O.
[1]
;
Carnier, June
[1]
;
Caranti, Danielle A.
[1]
;
Tock, Lian
[1]
;
Tufik, Sergio
[3]
;
de Mello, Marco Tulio
[1, 3]
;
Damaso, Ana R.
[2, 1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Paulista Med Sch, Nutr Postgrad Program, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
[3] Univ Fed Sao Paulo, Paulista Med Sch, Dept Psychobiol, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ADOLESCENT HEALTH; v. 49, n. 3, p. 300-305, SEP 2011. |
| Citações Web of Science: | 5 |
| Resumo | |
Objective: The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein {[}AgRP], neuropeptide Y {[}NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone {[}alpha-MSH]), in obese adolescents. Methods: A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15-19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, alpha-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks). Results: At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p<.05). The multidisciplinary therapy decreased NPY and AgRP values and increased alpha-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy. Conclusions: We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents. (C) 2011 Society for Adolescent Health and Medicine. All rights reserved. (AU) | |
| Processo FAPESP: | 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |