| Texto completo | |
| Autor(es): |
Hayashi, Marcio
;
Burtoloso, Antonio C. B.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY-A EUROPEAN JOURNAL; v. 30, n. 21, p. 6-pg., 2024-02-22. |
| Resumo | |
Organic molecules containing fluorine and sulfur atoms represent a large percentage of approved pharmaceuticals. Those with combination of both S and F atoms in their structure such as Xtandi, approved in 2012 for prostate cancer, indicates the importance of synthetic methods that accommodates both atoms in an organic moiety. In this study, a novel aspect of sulfoxonium ylide reactivity was explored, unveiling a streamlined and mild synthesis method for gem-difluorinated keto-sulfoxides. Our protocol offers a direct and practical approach to prepare these compounds in 14-80 % chemical yields, that were represented by 21 examples. NMR studies and Hammett correlations gave strong evidence about the mechanism of this transformation. (AU) | |
| Processo FAPESP: | 20/15230-5 - Centro de Pesquisa e Inovação de Gases de Efeito Estufa - RCG2I |
| Beneficiário: | Julio Romano Meneghini |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Centros de Pesquisa Aplicada |