| Texto completo | |
| Autor(es): |
Arruda, Bruna Petrucelli
;
Cruz-Ochoa, Natalia Andrea
;
Serra, Fernando
;
Xavier, Gilberto Fernando
;
Nogueira, Maria Ines
;
Takada, Silvia Honda
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE; v. 84, n. 6, p. 13-pg., 2024-06-10. |
| Resumo | |
Hypoxia in preterm infants is a clinical condition that has been associated with cognitive and behavioral disturbances for which treatment strategies are strongly required. Melatonin administration following brain insults has been considered a promising therapeutic strategy due to its antioxidant and anti-inflammatory effects. Not surprisingly, it has been extensively studied for preventing disturbances following brain injury. This study evaluated the effects of melatonin on developmental disturbances, memory disruption, and hippocampal cell loss induced by neonatal anoxia in rats. Neonatal Wistar rats were subjected to anoxia and subsequently treated with melatonin. Later, maturation of physical characteristics, ontogeny of reflexes, learning and memory in the Morris water maze (MWM), and estimates of the number of hippocampal neurons, were evaluated. Melatonin treatment attenuated (1) female anoxia-induced delay in superior incisor eruption, (2) female anoxia-induced vibrissae placement reflexes, and (3) male and female anoxia-induced hippocampal neuronal loss. Melatonin also promoted an increase (5) in swimming speeds in the MWM. In addition, PCA analysis showed positive associations between the acoustic startle, auditory canal open, and free fall righting parameters and negative associations between the male vehicle anoxia group and the male melatonin anoxia group. Therefore, melatonin treatment attenuates both anoxia-induced developmental deficits and hippocampal neuronal loss. Neonatal Wistar rats were subjected to anoxia and then treated with melatonin. Melatonin treatment attenuated female anoxia-induced delay in superior incisor eruption and vibrissae placement reflexes and male and female anoxia-induced hippocampal neuronal loss and promoted an increase in swimming speed in the Morris water maze. image (AU) | |
| Processo FAPESP: | 17/05218-5 - Efeito da fotobioestimulação em diferentes neuropatias periférica em ratos. |
| Beneficiário: | Marucia Chacur |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/16268-6 - Impacto da neuroinflamação e da participação do eixo intestino-cérebro na mielinização em modelo de anóxia neonatal em roedores combinado à inflamação perinatal por ativação imune materna |
| Beneficiário: | Silvia Honda Takada |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |